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Celastrol powder Raw Materials CAS 34157-83-0
Product Overview:
Celastrol powder, also known as Celastrol, is a natural product with various biological activities. Celastrol CAS 34157-83-0 has strong antioxidant, anti-cancer neovasculangiogenesis and anti-rheumatoid effects. Celastrol Raw Materials are mainly derived from the root bark of Tripterygium wilfordii.
Celastrol powder Raw Materials CAS 34157-83-0 Attributes
CAS:34157-83-0
MF:C29H38O4
MW:450.61
EINECS:636-472-5
Specification:99% min Celastrol powder
Sample:Celastrol powder
Appearance: red powder
Storage: Cool Dry Place
Brand: Ausreson
Shelf Life: 2 Years
Test Method: HPLC
Celastrol powder Raw Materials CAS 34157-83-0 Details
Uses and synthesis of Celastrol powder
Celastrol powder, also known as Celastrol, is a natural product with various biological activities. Celastrol CAS 34157-83-0 has strong antioxidant, anti-cancer neovasculangiogenesis and anti-rheumatoid effects. Celastrol Raw Materials are mainly derived from the root bark of Tripterygium wilfordii.
Functions of Celastrol powder
- Celastrol powder has strong antioxidant, anti-cancer neovascularization and anti-rheumatoid effects.
- A potent proteasome inhibitor that has been shown to induce apoptosis of cancer cells by inhibiting proteasome activity
Applications of Celastrol powder
1. Anti-inflammatory and immunomodulatory
Treat rheumatoid arthritis, exerting a potent anti-inflammatory effect by inhibiting NF-κB and inflammatory cytokines (such as iNOS)
Improve experimental colitis, regulate immune response by activating the autophagy pathway
2. Anti-tumor therapy
Inhibit castration-resistant prostate cancer (CRPC) by downregulating AR signaling pathway and hERG channel expression
Induce apoptosis of triple-negative breast cancer (TNBC) cells, targeting PI3K/Akt/mTOR pathway
Enhance the sensitivity of lung cancer cells to DNA-damaging drugs by consuming FANCD2 protein
3. Metabolic disease intervention
Significantly reduce obesity, reducing body weight by 45% by enhancing leptin sensitivity (mouse experiment)
4. Neuroprotection and degenerative diseases
Inhibit dopaminergic neuron death in Parkinson's disease, activate mitochondrial apoptosis pathway
Penetrate the blood-brain barrier to regulate neuroinflammation in Alzheimer's disease
5. Research tool development
Fluorescently labeled derivatives (such as FITC-Celastrol) for pharmacokinetic tracking and target validation
Biotinylated versions for proteomics and drug interaction studies
Physicochemical Property of Celastrol powder
Celastrol CAS 34157-83-0 is insoluble in water, but soluble in dimethyl sulfoxide and anhydrous ethanol.
Product method of Celastrol powder
Celastrol Raw Materials are derived from the anti-cancer active ingredients of Tripterygium wilfordii and Ophiodon wilfordii of Euonymaceae.
1. Natural extraction process
Raw material selection: mainly extracted from the root bark of Celastraceae plants (such as Tripterygium wilfordii and Diplocopithecus strychnifolius)
Ultrasound-assisted extraction
Solvent: anhydrous ethanol
Conditions: temperature 46°C, ultrasonic power 60W, liquid-to-solid ratio 30mL/g, time 20 minutes, extraction rate 3.116mg/g3
Column chromatography purification
Three-step purification: polyamide column (methanol: water = 3:1) → silica gel column (petroleum ether: ethyl acetate gradient elution) → gel column (methanol elution), final purity > 98%
2. Chemical synthesis and modification
Glucosamine modification: Celastrol carboxyl is coupled to glucosamine by EDC/PyBOP activator to synthesize attenuated derivatives (Cel-GlcN)
3. Quality control
HPLC detection: The mobile phase is methanol-0.1% phosphoric acid water (88:12), the detection wavelength is 425nm, and the external standard method is used for quantification
