99% N-acetyl Cysteine Nac Powder Organic N-acetyl-l-cysteine

Product name:N-Acetyl L-Cysteine

CAS:616-91-1

MF:C5H9NO3S

MW:163.19

EINECS:210-498-3

Specification:99% min N-Acetyl-L-cysteine powder

Sample:N-Acetyl-L-cysteine powder Avaliable

Appearance:white powder

Storage: Cool Dry Place

Brand:Ausreson

Shelf Life: 2 Years

Test Method: HPLC

Uses and Effect of N-Acetyl-L-cysteine powder.

N-Acetyl-L-cysteine powder, commonly referred to as NAC, is known for its powerful antioxidant properties. By neutralizing harmful free radicals in the body, N-Acetyl-L-cysteine CAS 616-91-1 helps prevent oxidative stress and supports overall cellular health. In addition, N-Acetyl-L-cysteine Raw Materials play a vital role in the production of glutathione, an important antioxidant that AIDS in detoxification and immune system function.

1. Mucolytic effect

NAC reduces sputum viscosity and promotes expectoration by decomposing the disulfide bonds of mucin in sputum. It is suitable for sputum viscosity or obstruction caused by chronic obstructive pulmonary disease (COPD), bronchitis, emphysema and other diseases.

2. Antioxidant effect

As a glutathione precursor, NAC can improve the body's antioxidant capacity, neutralize free radicals, reduce oxidative stress damage, and has an auxiliary therapeutic effect in acute lung injury and chronic inflammatory diseases.

3. Detoxification and liver protection

NAC is a specific antidote for acetaminophen (paracetamol) poisoning. It prevents liver cell necrosis by supplementing glutathione. In addition, it also has a protective effect on alcohol, heavy metal or drug-induced liver damage.

4. Other potential applications

Studies have shown that NAC may improve the symptoms of mental illness (such as obsessive-compulsive disorder and bipolar disorder), but the evidence is not yet sufficient.
In chronic kidney disease and cardiovascular disease, it may delay the progression of the disease through antioxidant mechanisms.

Functions of N-Acetyl-L-cysteine powder

Antioxidant effect: NAC is converted into glutathione in the body, which has a strong antioxidant effect, can remove free radicals and protect cells from damage.

Mucolytic effect: NAC can decompose the disulfide bonds in sputum, reduce the viscosity of sputum, and help expectorate.

Detoxification effect: NAC can combine with certain poisons to reduce their toxicity, has a certain detoxification effect, and is often used to rescue acetaminophen poisoning.

Immunomodulatory effect: NAC can regulate the function of the immune system and enhance the body's resistance.

Other effects: NAC may also have anti-inflammatory and anti-cancer effects

Drug interactions of N-Acetyl-L-cysteine powder.

This product is contraindicated with iodized oil, chymotrypsin, and trypsin.

When used in combination or alternating with isoproterenol, the efficacy of this drug can be improved and adverse reactions can be reduced.

When used in combination or alternating with isoproterenol, the efficacy of this drug can be improved and adverse reactions can be reduced.

When used in combination with nitroglycerin, it can increase the occurrence of hypotension and headache. Acidic drugs can reduce the effect of this product. This product can significantly increase the excretion of gold preparations and weaken the antibacterial activity of penicillin, tetracycline, and cephalosporin drugs, so it is not suitable for use with these drugs. If necessary, it can be used alternately at an interval of 4 hours.

Applications of N-Acetyl-L-cysteine powder.

Medical field: NAC can be used to treat respiratory diseases such as chronic obstructive pulmonary disease and bronchitis, as well as to treat acetaminophen poisoning.

Dietary supplements: NAC is often made into dietary supplements to enhance antioxidant capacity, protect the liver, and improve respiratory health

Production method of N-Acetyl-L-cysteine powder

The process of producing N-acetyl-L-cysteine ​​mainly includes two steps: neutralization and acetylation.

First, the neutralization step is carried out: dissolve L-cysteine ​​hydrochloride without crystal water in 0.8 times distilled water, dissolve it by slightly heating it in a water bath, and then filter and collect the filtrate. Add ethanol (95%) to the filtrate, then add pyridine, cool it to an ice water bath, place it in the refrigerator overnight to crystallize, filter, wash the crystals, and dry them with chloroform to finally obtain L-cysteine.

The acetylation process is more delicate: put L-cysteine ​​into the reaction tank, add glacial acetic acid and chloroform, and keep stirring vigorously. Heat the interlayer of the reaction tank to about 35°C, and after stopping heating, the temperature rises to 82-85°C. To prevent the temperature from being too high, it will start cooling at 70°C and stir at about 50°C for half an hour.
After filtering, concentrate the solution. When it becomes thicker, add an appropriate amount of water to continue concentrating. Repeat this process until the concentrate is about 1.8 times of L-cysteine. After cooling, add a small amount of L-cysteine ​​crystals, refrigerate overnight for crystallization, filter and squeeze dry, wash with ether to obtain crude acetylcysteine.

Finally, refine: the crude product is dissolved in 0.5-0.6 times distilled water, decolorized by activated carbon, filtered, the filtrate is cooled and crystallized again, filtered, squeezed dry, washed with ether, and finally vacuum dried to obtain pure N-acetyl-L-cysteine.