Butenafine powder Raw Materials CAS 101828-21-1

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Uses and synthesis of Butenafine powder

Butenafine powder is a derivative of benzoylamine. Its mechanism of action is to selectively inhibit fungal squalene cycoperoxidase, interfere with ergosterol biosynthesis in fungal cell walls, affect lipid metabolism of fungi, and cause fungal cell damage or death, thus playing a bactericidal and antibacterial role. The inhibition of fungal ergosterol synthesis by Butenafine made fungal cell membranes more sensitive to the direct cell membrane destruction of butenafine. In addition, human trials have confirmed that Butenafine powder has outstanding anti-inflammatory activity and can eliminate erythematous skin lesions caused by UVB exposure. Naftifen also has a strong anti-inflammatory effect, while terbinafine has no such effect.

Applications/Functions of Butenafine powder

1. Butenafine powder is a dermatological drug used for the treatment of superficial skin fungal infections caused by dermatophyton, such as tinea handi, tinea pedis (especially keratosis and thickening), tinea corporis, and tinea jock. Can also be used for tinea capitis.
2. Butenafine is used as an antifungal agent

Physicochemical Property of Butenafine powder

Production methodprocess of Butenafine powder

Butenafine powder was prepared from 1-naphthalene carboxylic acid by chlorination with sulfone chloride, which was condensed with 1- (4-tert-butylbenzene) -n-methylmethylmethylamine to obtain N- (4-tert-butylbenzyl) -n-methyl-1-naphthalamic acid, and then reduced by lithium aluminum hydride to form salt.

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