Albendazole powder Raw Materials CAS 54965-21-8

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Uses and synthesis of Albendazole powder

​​​​Albendazole powder is white or white-like powder, odorless, tasteless, insoluble in water, slightly soluble in acetone or chloroform. Albendazole is a broad spectrum dewormer with high efficiency and low toxicity. Clinical can be used to drive roundworm, pinworm, tapeworm, whipworm, hookworm, strongyloides faecalis and so on. After metabolizing to sulfoxides or sulfones in the body, it inhibits the absorption of glucose by the parasite, leading to the depletion of glycogen, or inhibits the fumarate reductase system, blocking the production of ATP, so that the parasite cannot survive and reproduce. Albendazole is a highly effective and broad-spectrum insecticidal drug of benzimidazole, which has a broad insecticidal spectrum and the strongest insecticidal action among benzimidazole. It is highly active to nematodes, schistosoma and tapeworms, and has a significant inhibitory effect on egg development.

​​​​Applications/Functions of Albendazole powder

1. ​Albendazole powder is used to control Chinese cabbage downy mildew, rice blast, tobacco powdery mildew, anthrax, etc.
2. ​Albendazole is a highly effective broad-spectrum dewormer. It can block the absorption of various nutrients and glucose by the insect body, resulting in the depletion of glycogen, which makes the parasite unable to survive and reproduce. It is used to treat single or mixed feelings caused by roundworm, pinworm, whipworm, hookworm, etc.
3. ​Albendazole is a highly effective, broad-spectrum insecticidal drug, and has significant effects on liver fluke, tapeworm, lung and gastrointestinal nematodes. Benzimidazole is the strongest of the benzimidazole drugs, is currently the first choice for the prevention and treatment of livestock and poultry parasitic diseases.

​​​​Physicochemical Property of Albendazole powder

​​​Albendazole white to light yellow crystalline powder, odorless, melting point 208 ~ 210℃, insoluble in water, slightly soluble in hot dilute hydrochloric acid, acetone or chloroform, soluble in methanol, ethanol or acetic acid.

​​​Production methodprocess of Albendazole powder

​O-nitroaniline was used as raw material. O-nitroaniline first reacts with sodium thiocyanate to form 2-nitro-4-thiocyanide in the condition of chlorination, then reacts with bromopropane to form 2-nitro-4-propyl thiocyanide, which is reduced by sodium sulfide to 2-amino-4-propyl thiocyanide, and finally synthesizes Albendazole powder with methyl cyanoformate

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